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Published on: May 27, 2022
Role of low-dose estrogen-testosterone combination therapy in men with oligospermia
1Arogya Niketan Private Limited, Uttarpara, India. purushottamsah@hotmail.com
Objective:
To determine if low doses of estrogen and testosterone can improve the semen quality in oligospermic men.
Design:
Prospective, nonrandomized, noncontrolled, clinical study.
Setting:
Primary level care in private practice.
Patient(S):
Fourteen physically healthy and androgenized oligospermic men were selected for the study.
Intervention(S):
Combined low-dose estrogen-testosterone was administered orally for 4 months.
Main Outcome Measure(S):
Semen parameters.
Result(S):
Nine cases (64.2%) showed definite improvement in the semen quality, five cases (35.8%) did not show much improvement. The wives of three patients (21.4%) became pregnant within 6 months of the initiation of therapy.
Conclusion(S):
Low-dose estrogen and testosterone may significantly improve the semen quality in men with oligospermia.
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