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FAIR excluding radiation damping (FAIRER)
1Johns Hopkins University Medical School, Department of Radiology, Baltimore, Maryland 21205-2195, USA.
Magnetic Resonance in Medicine
|October 31, 1998
Summary
Radiation damping complicates flow-sensitive alternating inversion recovery (FAIR) MRI. A new FAIRER technique uses weak gradients to suppress damping, improving flow measurements in phantoms and cat brains.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Biomedical Engineering
- Medical Physics
Background:
- Flow-sensitive alternating inversion recovery (FAIR) is a key MRI technique for quantifying blood flow.
- Radiation damping artifacts can compromise the accuracy and calibration of FAIR measurements.
- Existing methods struggle with phantom calibration and in vivo flow inaccuracies due to these artifacts.
Purpose of the Study:
- To address the limitations of the FAIR technique caused by radiation damping.
- To introduce a modified FAIR sequence, termed FAIRER (FAIR excluding radiation damping).
- To demonstrate the efficacy of FAIRER in overcoming calibration and accuracy issues.
Main Methods:
- Development of the FAIRER technique, incorporating very weak magnetic field gradients (0.06 G/cm).
- Application of gradients during inversion recovery, spin-echo, and predelay periods to suppress radiation damping.
- Validation using phantom studies and in vivo imaging of cat brains.
Main Results:
- FAIRER effectively suppresses radiation damping effects.
- Phantom calibration challenges associated with standard FAIR are resolved.
- Accurate flow measurements were achieved in vivo, as demonstrated in cat brain imaging.
Conclusions:
- The FAIRER technique provides a robust solution to radiation damping in FAIR MRI.
- This method enhances the reliability of quantitative flow measurements.
- FAIRER offers improved accuracy for both phantom calibration and in vivo applications.