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Related Experiment Videos

Axon deviation in the human lamina cribrosa

J E Morgan1, G Jeffery, A J Foss

  • 1Cardiff Eye Unit, University Hospital of Wales.

The British Journal of Ophthalmology
|November 3, 1998
PubMed
Summary

A study tracked retinal ganglion cell axons in human eyes. Some axons deviate within the lamina cribrosa, suggesting potential vulnerability in glaucoma.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Anatomy

Background:

  • Retinal ganglion cell axons form the optic nerve.
  • The lamina cribrosa is a crucial structure at the optic nerve head.
  • Understanding axon pathways is vital for optic neuropathies.

Purpose of the Study:

  • To investigate the anatomical course of individual retinal ganglion cell axons through the human lamina cribrosa.
  • To identify variations in axon trajectories within this optic nerve head structure.

Main Methods:

  • Utilized retrograde tracer (horseradish peroxidase) to label retinal ganglion cell axons.
  • Applied tracer directly to the optic nerve in two human eyes.
  • Examined axon pathways within the lamina cribrosa.

Main Results:

  • Most retinal ganglion cell axons followed a direct path through the lamina cribrosa.
  • A notable percentage (8-12%) of axons deviated, passing between cribrosal plates.
  • Axon deviation occurred in both central and peripheral regions of the optic disc.

Conclusions:

  • The deviating axon pathways may represent a vulnerability.
  • These specific axons could be susceptible to compression within the lamina cribrosa.
  • This finding has implications for understanding glaucomatous damage and other conditions increasing intraocular pressure.

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