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Related Experiment Videos

Glucocorticoids decrease c-fos expression in human nasal polyps in vivo

J N Baraniuk1, G Wong, M Ali

  • 1Division of Rheumatology, Immunology and Allergy, Georgetown University, Washington, DC 20007-2197, USA.

Thorax
|November 3, 1998
PubMed
Summary

Glucocorticoids reduce c-fos expression in nasal polyps. This suggests a mechanism for how these steroids help treat nasal polyps by modulating the AP-1 transcription factor.

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Area of Science:

  • Molecular Biology
  • Immunology
  • Otorhinolaryngology

Background:

  • c-Fos protein forms the AP-1 transcription factor, regulating inflammatory genes.
  • AP-1 is implicated in nasal polyp formation.
  • Glucocorticoids may counteract AP-1 activity, explaining their therapeutic effect in nasal polyps.

Purpose of the Study:

  • To investigate the in vivo effect of glucocorticoids on c-Fos expression in human nasal polyps.

Main Methods:

  • Immunohistochemistry assessed c-Fos-immunoreactive material (c-fos-irm) in nasal polyps from steroid-naive and beclomethasone dipropionate (BDP)-treated subjects, and normal nasal mucosa.
  • Compared c-fos-irm levels between groups.

Main Results:

  • c-Fos mRNA was detected in all samples.

Related Experiment Videos

  • c-fos-irm was significantly reduced in BDP-treated subjects compared to steroid-naive subjects (p = 0.007).
  • c-Fos-irm was localized to epithelial cells and glands, with lower intensity in normal mucosa.

    • Conclusions:

    • Glucocorticoids modulate c-Fos expression in human airway epithelial cells in vivo.
    • This modulation may involve the AP-1 transcription factor.
    • Findings support a mechanism for glucocorticoid action in nasal polyp treatment.