Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Trisomy 14 and leukemia

¹Quest Diagnostics Inc., San Juan Capistrano, CA 92690-6130, USA.

Cancer Genetics and Cytogenetics

|November 3, 1998

Summary

This summary is machine-generated.

Trisomy 14, a chromosomal abnormality, is linked to myeloid malignancies like myelodysplasia. This study found 11 cases, highlighting its nonrandom association with these blood cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Associations of meteorological variability with sesame yield in semi-arid Bundelkhand region of India.

Scientific reports·2026

Same author

Floral and pollination biology of dragon fruit reveals strategies for enhancing productivity through pollination management and reproductive window extension.

Scientific reports·2025

Same author

Innovative and polygonal trend analysis of temperature in agro climatic zones of India.

Scientific reports·2024

Same author

Health effects of selected environmental Exposomes Across the Life courSe in Indian populations using longitudinal cohort studies: GEOHealth HEALS Study protocol.

BMJ open·2024

Same author

India led health innovation(s) for achieving the SDG health goal in the global South.

Perspectives in public health·2022

Same author

COVID-19: Impact analysis and recommendations for power sector operation.

Applied energy·2020

Same journal

Letter to the editor regarding the article "Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: pathogenic and prognostic implications".

Cancer genetics and cytogenetics·2010

Same journal

A novel t(10;12)(q21;p13) involving ETV6 in a patient with acute myeloid leukemia.

Cancer genetics and cytogenetics·2010

Same journal

A case of acute myeloid leukemia initially treated as chronic lymphocytic leukemia: what do we know about t(4;12)(q12;p13)?

Cancer genetics and cytogenetics·2010

Same journal

Myelodysplastic syndrome with isochromosome 5p and trisomy 8 after treatment of a multiple myeloma.

Cancer genetics and cytogenetics·2010

Same journal

Chromosomal imbalances in urinary bladder paraganglioma.

Cancer genetics and cytogenetics·2010

Same journal

A pericentric inv(9)(p22q34) of the der(9)t(9;22)(q34;q11.2) is a recurrent secondary anomaly in Ph-positive leukemia.

Cancer genetics and cytogenetics·2010

See all related articles

Area of Science:

Cytogenetics
Hematology
Oncology

Background:

Trisomy 14 is a rare chromosomal abnormality.
Its association with myeloid malignancies requires further investigation.

Observation:

Eleven cases of trisomy 14 as the sole abnormality were identified.
Eight cases presented with myelodysplasia, two with mixed myelodysplastic/myeloproliferative features, and one with acute myeloid leukemia.
Abnormal red blood cell morphology was common.

Findings:

Trisomy 14 occurred in 11 patients, with isochromosome 14q in 4 cases and mosaicism in 8.
The median age of affected individuals was 77 years.
Survival ranged from 1 month to 3 years.

Implications:

Related Experiment Videos

This study supports trisomy 14 as a nonrandom cytogenetic abnormality in myeloid malignancies.
Further research is warranted to understand the role of trisomy 14 in hematologic cancers.
Identifying chromosomal abnormalities like trisomy 14 aids in diagnosing and understanding myeloid cancers.