Related Experiment Video
Updated: Jul 22, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Trisomy 6 and double minute chromosomes in a case of chronic myelomonocytic leukemia
C Sambani1, D T Trafalis, G Vessalas
1Health Physics and Environmental Hygiene Unit, Institute N. T.-R. P., N.C.S.R Demokritos, Athens, Greece.
Abstract:
A 65-year-old woman with chronic myelomonocytic leukemia was shown to have trisomy 6 and multiple double minute chromosomes. The patient had no history of prior exposure to any mutagenic or carcinogenic agents. To our knowledge, this is the first report for presence of only these two aberrations. The expression of several oncoproteins and onco-related proteins was detected immunohistochemically in bone marrow cells. Among them, only the bcl-2 oncoprotein was positively stained in 100% of myeloblasts. Although the c-myc oncogene is frequently reported to be overexpressed in myeloid disorders with double minutes and associated with chemotherapy resistance and disease aggressiveness, in our case, the c-myc oncoprotein was not positively expressed. The patient received chemotherapy and complete hematological remission was successfully achieved.
More Related Videos
Related Concept Videos
Meiosis I
Karyotyping
Nondisjunction
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

