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Hyperprolactinemia: an inductor of neoplastic changes in endometrium? A report of two cases
1Department of Obstetrics and Gynecology, Institut Universitari Dexeus, Universitat Autònoma de Barcelona, Spain.
Abstract:
Estrogen-dependent endometrial carcinomas habitually arise through a precursor lesion such as endometrial hyperplasia. The hormonal environment of these patients remains unclear. Two cases of neoplastic changes in the endometrium of patients with a chronic hyperprolactinemia are presented. Despite the treatment with bromocriptine both patients developed endometrial adenocarcinomas. Possible mechanisms involved in the pathogenesis of these tumors are discussed.