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Lincomycin-clindamycin-associated psuedomembranous colitis

J F Munk, B T Collopy, J L Connell

    The Medical Journal of Australia
    |July 17, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    Lincomycin and clindamycin can cause acute pseudomembranous colitis. Severe cases may benefit from corticosteroid therapy, alongside supportive care.

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Lincomycin and clindamycin are antibiotics sometimes associated with severe gastrointestinal side effects.
    • Acute pseudomembranous colitis is a serious condition that can arise during or after antibiotic treatment.

    Observation:

    • A five-month period revealed five cases of lincomycin-clindamycin-associated acute pseudomembranous colitis.
    • Patients presented with watery diarrhea; two had severe, fulminant colitis.
    • Diagnosis can be confirmed via sigmoidoscopy.

    Findings:

    • Mild colitis cases responded to antibiotic withdrawal and symptomatic treatment.
    • Severe colitis cases showed rapid improvement with parenteral corticosteroids and supportive therapy.
    • The clinical, histological, and radiological severity varied among the cases.

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    Implications:

    • Healthcare providers should consider colitis in patients with diarrhea during or after lincomycin/clindamycin therapy.
    • Antibiotic stewardship is crucial to avoid indiscriminate use of these drugs.
    • Corticosteroids appear safe and effective for severe antibiotic-associated colitis.