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Stroke and cocaine or amphetamine use

D B Petitti1, S Sidney, C Quesenberry

  • 1Kaiser Permanente Medical Care Program, Southern California, USA.

Epidemiology (Cambridge, Mass.)
|November 3, 1998
PubMed
Summary
This summary is machine-generated.

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Cocaine and amphetamine use significantly increases stroke risk in women aged 15-44. This study highlights stimulant drug use as a critical factor for stroke in a diverse, insured population.

Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Existing research on stimulant-associated stroke primarily relies on case series.
  • Previous epidemiological studies often focused on socioeconomically disadvantaged or minority populations.
  • A need exists for research in more diverse populations to understand stroke risk factors.

Purpose of the Study:

  • To investigate the association between cocaine and/or amphetamine use and stroke.
  • To assess this association in a socioeconomically diverse, insured urban population.
  • To determine if stimulant use is an independent risk factor for stroke in women of reproductive age.

Main Methods:

  • A case-control study was conducted within Kaiser Permanente of Northern and Southern California.

Related Experiment Videos

  • Incident strokes in women aged 15-44 were identified over a 3-year period.
  • Controls were randomly selected and matched on age and usual care facility; data collected via interviews.

    • Main Results:

    • 347 stroke cases and 1,021 controls were analyzed.
    • Univariate analysis showed an odds ratio of 8.5 for stroke associated with stimulant use.
    • Adjusted analysis revealed an odds ratio of 7.0, indicating a strong association.

    Conclusions:

    • Cocaine and/or amphetamine use is a significant risk factor for stroke in women aged 15-44.
    • The findings apply to a socioeconomically heterogeneous, insured urban population.
    • This study underscores the importance of considering stimulant use in stroke risk assessment.