Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vivo multiple spin echoes

A Bifone1, G S Payne, M O Leach

  • 1CRC Clinical Magnetic Resonance Research Group, The Institute of Cancer Research, Sutton, SM2 5PT, United Kingdom. bifone@icr.ac.uk

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|November 4, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Environmental & load data: 1:15 Scale tidal turbine subject to a variety of regular wave conditions.

Data in brief·2019
Same author

Fast and Sensitive Detection of Paramagnetic Species Using Coupled Charge and Spin Dynamics in Strongly Fluorescent Nanodiamonds.

ACS applied materials & interfaces·2019
Same author

phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol-preferring from genetically heterogenous rats.

Addiction biology·2018
Same author

An all-optical single-step process for production of nanometric-sized fluorescent diamonds.

Nanoscale·2018
Same author

Magnetic Resonance Spectroscopy to Study Glycolytic Metabolism During Autophagy.

Methods in enzymology·2017
Same author

Extended T2-IVIM model for correction of TE dependence of pseudo-diffusion volume fraction in clinical diffusion-weighted magnetic resonance imaging.

Physics in medicine and biology·2016
Same journal

Localization-driven exchange contrast in diffusion exchange spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

4.5 Tesla superconducting miniature magnet in liquid nitrogen.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Folding and unfolding dynamics of a DNA aptamer studied by heteronuclear <sup>1</sup>H-<sup>13</sup>C correlation zz-exchange spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Multi-spin control from one-spin pulses.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Altering MRI rotating frame relaxations by changing the truncation level of Hyperbolic Secant pulse.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Effects of proton exchange on the lifetimes of long-lived states in aliphatic chains.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
See all related articles

Nuclear polarization can refocus multiple spin echoes, observable in vivo using clinical MRI. This study explores spatial localization and compares signal amplitudes to theory, discussing medical applications.

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Nuclear Magnetic Resonance (NMR)
  • Biophysics

Background:

  • Nuclear polarization can generate demagnetizing fields.
  • These fields have the potential to induce spin echo refocusing.
  • Understanding this phenomenon is key for advanced MRI techniques.

Purpose of the Study:

  • To demonstrate the in vivo observation of multiple spin echoes induced by nuclear polarization.
  • To investigate strategies for spatial localization of these signals.
  • To compare experimental findings with theoretical predictions and explore medical applications.

Main Methods:

  • Utilized a clinical Magnetic Resonance Imaging (MRI) system at 1.5 Tesla.
  • Acquired multiple spin echo signals in vivo from healthy volunteers.

Related Experiment Videos

  • Performed spatial localization of signals and analyzed signal amplitude dependence on experimental parameters.

    • Main Results:

    • Successfully observed multiple spin echoes in vivo.
    • Reported studies in brain white matter and skeletal muscle.
    • Demonstrated agreement between experimental signal amplitudes and theoretical models.

    Conclusions:

    • Nuclear polarization-induced demagnetizing fields enable multiple spin echo generation in vivo.
    • Spatial localization strategies are feasible for clinical MRI.
    • Findings support the potential for novel MRI contrast mechanisms and medical applications.