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Related Experiment Videos

Simplified interpretative format for assessing test interference: studies with hemoglobin-based oxygen carrier

S C Kazmierczak1, P G Catrou, D Boudreau

  • 1Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Greenville, NC 27858-4354, USA. kaz@brody.med.ecu.edu

Clinical Chemistry
|November 4, 1998
PubMed
Summary
This summary is machine-generated.

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Interference in lab tests can vary with analyte and interferent levels. A new graphical method helps assess clinical acceptability of results with hemoglobin-based oxygen carriers.

Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Analytical Toxicology

Background:

  • Substances like hemoglobin frequently cause errors in laboratory medicine analytical processes.
  • Standard interference assessment guidelines often overlook the impact of analyte and interferent concentrations.
  • Previous studies indicate interference effects can differ significantly based on specimen concentrations.

Purpose of the Study:

  • To develop and present an experimental protocol for investigating concentration-dependent interference effects.
  • To introduce a novel two-dimensional graphical format for evaluating clinical acceptability of test results in the presence of interferents.
  • To assess interference from hemoglobin-based oxygen carrier solutions.

Main Methods:

  • An experimental protocol using an orthogonally arranged matrix with increasing analyte and interferent concentrations was developed.

Related Experiment Videos

  • Multiple regression analysis was employed to evaluate measured analyte concentrations within the matrix.
  • A two-dimensional graphical format was used to assess clinical acceptability based on Clinical Laboratory Improvement Amendments of 1988 criteria.

    • Main Results:

    • The developed protocol allows for determination of the magnitude, direction, and significance of interference effects.
    • Multiple regression analysis effectively quantifies interference based on varying analyte and interferent concentrations.
    • The graphical format facilitates the evaluation of clinical acceptability of test results in specimens with hemoglobin-based oxygen carriers.

    Conclusions:

    • Interference effects in laboratory medicine are not always independent of analyte and interferent concentrations.
    • The proposed experimental protocol and graphical format provide a robust method for interference assessment.
    • This approach aids in judging the clinical acceptability of test results when hemoglobin-based oxygen carriers are present.