Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Maternal serum inhibin A can predict pre-eclampsia

H Cuckle¹, I Sehmi, R Jones

¹Centre for Reproduction, Growth and Development, University of Leeds, UK.

British Journal of Obstetrics and Gynaecology

|November 4, 1998

Summary

Maternal serum inhibin A levels are significantly elevated in the second trimester for women who later develop pre-eclampsia, offering potential for early detection and intervention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Change in prevalence of preterm birth in Israel following publication of national guidelines recommending routine sonographic cervical-length measurement at 19-25 weeks' gestation.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022

Same author

Quality assessment of first-trimester screening for preterm pre-eclampsia.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022

Same author

Re: Routine first-trimester combined screening for pre-eclampsia: pregnancy-associated plasma protein-A or placental growth factor?

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022

Same author

Early pregnancy prediction of spontaneous preterm birth before 32 completed weeks of pregnancy using plasma RNA: transcriptome discovery and initial validation of an RNA panel of markers.

BJOG : an international journal of obstetrics and gynaecology·2021

Same author

United States' experience in nuchal translucency measurement: variation according to provider characteristics in over five million ultrasound examinations.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2021

Same author

Rethinking second-trimester Down-syndrome screening in the cell-free DNA era.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019

Area of Science:

Biochemistry
Obstetrics
Maternal-Fetal Medicine

Background:

Pre-eclampsia is a serious pregnancy complication.
Early detection of pre-eclampsia remains a clinical challenge.
Biomarkers for predicting pre-eclampsia are actively sought.

Purpose of the Study:

To investigate maternal serum inhibin A levels as a potential predictive marker for pre-eclampsia.
To compare inhibin A concentrations in women who develop pre-eclampsia versus healthy controls.

Main Methods:

Retrospective analysis of stored serum samples from 13-18 weeks gestation.
Inclusion of 28 pregnancies with pre-eclampsia and 701 controls.
Measurement of median inhibin A levels in maternal serum.

Main Results:

Significantly elevated median inhibin A levels (2.01 multiples of control median) were observed in women who developed pre-eclampsia (P < 0.001).
A high proportion of pre-eclampsia cases (82%) showed inhibin A levels above the normal median.
Elevated levels were also noted above the 75th, 90th, and 95th centiles in a substantial percentage of cases.

Conclusions:

Maternal serum inhibin A levels can be increased months prior to pre-eclampsia symptom onset.
This finding suggests inhibin A may serve as an early predictive marker for pre-eclampsia.
The elevated levels offer opportunities for studying the disease's early natural history and for potential treatment trials.

Related Experiment Videos