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Cancer--a degenerative disorder?

¹University Surgical Unit, The University of Leicester, UK.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|November 4, 1998

Summary

Cancer is a degenerative disease linked to aging, characterized by genomic control loss rather than just new neoplastic functions. This perspective, termed aldoplasia, impacts therapeutic strategy development.

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Area of Science:

Oncology
Genetics
Cell Biology

Background:

Cancer is predominantly observed in aging individuals and affects aging epithelia.
Accumulated changes in cell regulatory genes and DNA repair systems over time contribute to malignancy.
These changes involve genetic degeneration, from base pair mutations to aneuploidy, and impaired cellular control.

Purpose of the Study:

To explore the concept of cancer as a degenerative disease.
To analyze the implications of this degenerative view on cancer biology and treatment.
To introduce and define the term 'aldoplasia' for this phenomenon.

Main Methods:

Conceptual analysis of existing research on cancer and aging.
Review of genetic and cellular mechanisms underlying cancer development.
Literature synthesis to support the proposed concept.

Main Results:

Cancer involves a deterioration of normal genomic control and cellular regulation.
This degenerative aspect is as significant as the acquisition of neoplastic functions.
The proposed concept of aldoplasia encapsulates cancer as a loss of genomic integrity.

Conclusions:

Viewing cancer as a degenerative disease, or aldoplasia, offers a new framework for understanding its biology.
This perspective has significant implications for developing novel therapeutic strategies.
Aldoplasia highlights the role of aging-related genetic and cellular decline in cancer pathogenesis.

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