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Metallothionein expression in renal cancer
J I Izawa1, M Moussa, M G Cherian
1Department of Surgery, The University of Western Ontario, London, Canada.
Urology
|November 4, 1998
Summary
Metallothionein (MT) expression is inversely related to tumor grade in renal cell carcinoma. Higher MT levels were found in lower stage tumors, suggesting a role in cancer progression.
Area of Science:
- Oncology
- Biochemistry
- Pathology
Background:
- Metallothionein (MT) is implicated in carcinogenesis.
- Understanding MT's role in renal cell carcinoma (RCC) is crucial.
Purpose of the Study:
- Assess MT expression in human RCC via immunohistochemistry.
- Determine the relationship between MT expression and histopathologic findings, tumor grade, and stage.
Main Methods:
- Reviewed 28 archival RCC specimens and medical records.
- Performed immunohistochemical localization of MT using specific antibodies and avidin-biotin complex.
- Correlated MT staining intensity, extension, and site with histologic type, tumor grade, and pathologic stage.
Main Results:
- Predominant histologic type was clear cell variant.
- Greater MT immunoreactivity observed in Stage 2 tumors (P=0.028).
- Significant inverse relationship between tumor grade and MT staining intensity (P=0.007).
Conclusions:
- Inverse relationship between MT immunoreactivity and tumor grade suggests a role in RCC dedifferentiation.
- Increased MT in lower stage tumors may relate to rapid growth.
- Further research needed to clarify MT's role in RCC oncogenesis and prognosis.