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Angiosarcoma of the bladder: a review

J D Engel¹, T M Kuzel, M C Moceanu

¹Department of Urology, Northwestern University Medical School, Chicago, Illinois, USA.

|November 4, 1998

Summary

Bladder angiosarcoma is a rare and often fatal cancer. Multimodality therapy, combining surgery, chemotherapy, and radiotherapy, offers the best chance for survival in patients with this aggressive tumor.

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Area of Science:

Urologic Oncology
Vascular Neoplasms
Cancer Research

Background:

Angiosarcoma of the bladder is an exceedingly rare malignancy.
This tumor type has a poorer prognosis compared to angiosarcomas in more common locations.
Understanding the unique presentation, treatment, and clinical course is crucial for patient management.

Observation:

A review of 10 cases, including a new case, revealed diverse origins, including pre-existing hemangiomas and radiation-induced sarcomas.
Hematuria was a consistent presenting symptom across all reviewed cases.
While regional lymph nodes were often spared, local recurrence and distant metastasis were common.

Findings:

Treatment modalities varied significantly among the reported cases.

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Eight out of ten patients died within a median follow-up of 23 months, with five succumbing to tumor-related causes (mean survival 10.6 months).

The two most recent patients, treated with multimodality approaches, achieved tumor-free survival at 8 and 32 months.

Implications:

Optimal therapeutic strategies for bladder angiosarcoma remain undetermined but likely necessitate a multimodal approach.
Combining radical surgery with chemotherapy and radiotherapy may improve outcomes for patients with this rare cancer.
Further research into effective treatment protocols for bladder angiosarcoma is warranted.