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Synaptic integration in striate cortical simple cells

J A Hirsch1, J M Alonso, R C Reid

  • 1Laboratory of Neurobiology, The Rockefeller University, New York, New York, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 5, 1998
PubMed
Summary
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Simple cells in the visual cortex use intracortical inhibition for suppression, not just thalamic drive withdrawal. This inhibition operates dynamically, influencing neuronal output and receptive field properties.

Area of Science:

  • Neuroscience
  • Visual Cortex Physiology

Background:

  • Simple cells in the visual cortex are sensitive to oriented contours.
  • Their receptive fields have antagonistic on/off subregions with push-pull responses.

Purpose of the Study:

  • To investigate the generation and integration of excitation (push) and suppression (pull) in simple receptive fields.
  • To determine the mechanisms underlying suppression in the visual cortex.

Main Methods:

  • Whole-cell patch recordings from cat area 17 during visual stimulation.
  • Comparison of intracellular cortical responses with extracellular recordings from the lateral geniculate nucleus.

Main Results:

  • The temporal structure of excitatory input (push) mirrored thalamic inputs.

Related Experiment Videos

  • Intracortical inhibition appears to be the primary mechanism for suppression (pull).
  • Inhibition demonstrated a wide dynamic range, significantly increasing membrane conductance and modulating neuronal output.

    • Conclusions:

    • Intracortical inhibition is the dominant mechanism for suppression in simple visual receptive fields.
    • This inhibition dynamically shapes neuronal responses, affecting spike threshold and firing rates.