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Chromium levels in patients with internal diseases
11st Institute of Medical Chemistry and Biochemistry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Biochemistry and Molecular Biology International
|November 5, 1998
Summary
Chromium (Cr) levels vary by disease, with higher levels in hemodialysis patients and lower levels in hyperlipidemic patients. Monitoring Cr may be important for patient care and potential supplementation.
Area of Science:
- Biochemistry
- Trace Elements
- Metabolic Disorders
Background:
- Chromium (Cr) is an essential trace element vital for saccharide and lipid metabolism.
- Its precise role in human health and disease states requires further elucidation.
- Understanding Cr serum levels in various pathologies is crucial for clinical management.
Purpose of the Study:
- To quantify serum chromium concentrations across different disease groups: malignant, metabolic, and renal.
- To investigate the correlation between serum Cr levels and other biochemical parameters.
- To assess the impact of disease and treatment on Cr serum levels.
Main Methods:
- Serum Cr concentration was measured using advanced atomic absorption spectrometry with electrothermal atomization.
- Patient groups included hemodialysis (HD), diabetes mellitus (DM), lymphoproliferative disease (LP), and hyperlipidemia (HL).
- Correlations were analyzed with biochemical markers such as glucose, lipids, total protein, and apolipoproteins.
Main Results:
- Serum Cr levels were significantly elevated in hemodialysis patients (3.67 ± 0.35 µg/L) compared to controls (0.40 ± 0.12 µg/L).
- Cr levels were altered in diabetic (0.29 ± 0.08 µg/L) and lymphoproliferative disease patients (0.24 ± 0.07 µg/L).
- Hyperlipidemic patients exhibited decreased Cr levels (0.15 ± 0.03 µg/L). No significant correlations were found with most biochemical parameters, except for a marginal correlation with HDL-cholesterol.
Conclusions:
- Serum chromium levels exhibit distinct patterns across various disease states, notably elevated in hemodialysis patients.
- Current therapeutic interventions for diabetes and hyperlipidemia did not significantly alter serum Cr concentrations.
- Monitoring serum Cr may be beneficial for managing certain patient complications, with potential implications for chromium supplementation in conditions like hyperlipidemia.