Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dapsone syndrome--a five year retrospective analysis

R H Kumar1, M V Kumar, D M Thappa

  • 1Dept. of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry.

Indian Journal of Leprosy
|November 5, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topical Tacrolimus in Vitiligo: Consensus Paper from the Pigmentary Disorders Society.

Clinical, cosmetic and investigational dermatology·2024
Same author

Lack of association of <i>IL-10</i> (rs1800896) and <i>IL-13</i> (rs1800925) with non-segmental vitiligo susceptibility in South Indian population.

Indian journal of dermatology, venereology and leprology·2020
Same author

Association of PTPN22 gene polymorphism with non-segmental vitiligo in South Indian Tamils.

Postepy dermatologii i alergologii·2018
Same author

Clinical, dermoscopic and histopathological features of a rare cutaneous neural tumour.

Clinical and experimental dermatology·2018
Same author

Chronic inflammatory demyelinating polyneuropathy : clinical, electrophysiological and morphological study.

Neurology India·2018
Same author

Dermoscopic features of pilar leiomyomas.

The British journal of dermatology·2018
Same journal

Unilateral Cauliflower Ear due to Leprosy or Trauma - A Diagnostic Challenge.

Indian journal of leprosy·2018
Same journal

Pityriasis Rosea Localized to the Skin Patches of Leprosy. A Wolf's Isotopic Response?

Indian journal of leprosy·2018
Same journal

Cutaneous Sarcoidosis Misdiagnosed as Leprosy. Report of Two Cases and Review of Literature.

Indian journal of leprosy·2018
Same journal

Evaluation of New Antibacterial Drugs and their Combinations in a Murine Model to Identify Short Duration Alternative Chemotherapy for Leprosy.

Indian journal of leprosy·2018
Same journal

Evaluation of anti-bacterial activity of Rifapentine, Clarithromycin, Minocycline, Moxifloxacin, Ofloxacin and their combinations in Murine Model of Rifampicin Resistant Leprosy.

Indian journal of leprosy·2018
Same journal

Functioning and Disability in Leprosy.

Indian journal of leprosy·2018
See all related articles

Dapsone syndrome, a severe adverse reaction to dapsone medication, presents with diverse symptoms including fever and skin lesions. Most patients recover with conservative treatment or corticosteroids.

Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • Dapsone is a crucial medication for treating leprosy and other dermatological conditions.
  • Dapsone syndrome is a rare but serious hypersensitivity reaction to dapsone therapy.
  • Understanding the clinical spectrum and management of dapsone syndrome is vital for patient safety.

Purpose of the Study:

  • To analyze the clinical characteristics, manifestations, and outcomes of dapsone syndrome.
  • To identify key diagnostic indicators and management strategies for dapsone syndrome.
  • To evaluate the reliability of diagnostic tests for dapsone syndrome.

Main Methods:

  • Retrospective case series analysis of 17 patients diagnosed with dapsone syndrome between 1992 and 1997.

Related Experiment Videos

  • Clinical data collection including patient demographics, dapsone exposure, symptom onset, clinical presentation, laboratory findings, and treatment outcomes.
  • Review of diagnostic test results, including oral provocation and intradermal testing.

    • Main Results:

    • Seventeen cases of dapsone syndrome were identified, with a mean age of 27.8 years and a male to female ratio of 1.1:1.
    • Common manifestations included fever (16 cases), pruritus (15 cases), lymphadenopathy (14 cases), hepatomegaly (10 cases), and various cutaneous lesions.
    • Elevated ESR and liver enzymes were consistent findings; eight cases showed raised bilirubin and hemolytic anemia. Most patients achieved favorable outcomes with conservative management or oral corticosteroids.

    Conclusions:

    • Dapsone syndrome presents with a wide array of systemic and cutaneous manifestations, often mimicking other conditions.
    • Prompt recognition and discontinuation of dapsone are crucial for managing dapsone syndrome.
    • Conservative management or oral corticosteroids are effective treatment strategies, leading to favorable outcomes in most cases.