The neutrophil: one of the cellular targets of interleukin-10

Interleukin-10 exerts a wide spectrum of in vitro and in vivo biological activities implicated in the regulation of the inflammatory and immune responses. Among the different cell types affected by interleukin-10, monocyte/macrophages and lymphocytes appear to be particularly modified with regard to their function, morphology, and phenotype. However, recent studies performed in our laboratory, as well as by other groups, suggest that a number of functional activities of polymorphonuclear neutrophils are also subject to regulation by interleukin-10. In view of the central role of polymorphonuclear neutrophils in host defense processes and in amplifying inflammatory and immune reactions, the ability of interleukin-10 to act as a potent modulator of this cell type opens new perspectives as to the potential therapeutic utility of interleukin-10. This article reviews what is currently known about the effects of interleukin-10 on neutrophils.