Related Experiment Video
Updated: Aug 10, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
[Pathomechanism of pain in vertebral column diseases]
Abstract:
The pathological mechanism of pain in vertebral column diseases is discussed in accordance with the theory of Melzack and Wall taking into account both systems of pain sensation control at the spinal level and reticular formation level. The action of pain mediators is discussed as well. The main pathogenetic factors are: compression, stretching and ischaemia. Other factors, functioning particularly at the cervical spine level are, most frequently, developmental anomalies in the occipito-cervical area and faulty posture assumed during occupational work, as well as injuries which may be remote in time and forgotten. Elimination of pain perception may be obtained with surgical methods or by physicochemical means blocking the conduction of pain impulses.
Related Concept Videos
Nociception
Blood and Nerve Supply to the Bones
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Analgesia and Pain Management
Pain
Herniated Intervertebral Disc l: Introduction
Degenerative Disc Disease ll: Pathophysiology

