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Related Experiment Videos

Glutamine, exercise and immune function. Links and possible mechanisms

N P Walsh1, A K Blannin, P J Robson

  • 1Sport Health and Leisure Department, Trinity and All Saints University College, Leeds, England.

Sports Medicine (Auckland, N.Z.)
|November 5, 1998
PubMed
Summary
This summary is machine-generated.

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Glutamine, essential for immune cells, drops in athletes after prolonged exercise and in overtraining. Monitoring glutamine levels may help detect overtraining in athletes.

Area of Science:

  • Biochemistry
  • Exercise Physiology
  • Immunology

Background:

  • Glutamine is the most abundant amino acid in humans, crucial for rapidly dividing cells like leucocytes, supporting immune function.
  • Catabolic states such as trauma, infection, starvation, and prolonged exercise disrupt glutamine homeostasis.
  • Low plasma glutamine levels are observed after endurance events and in overtrained athletes, impacting immune cell function.

Purpose of the Study:

  • To investigate the impact of catabolic stress, particularly prolonged exercise, on plasma glutamine levels.
  • To explore the relationship between plasma glutamine levels and overtraining syndrome in athletes.
  • To assess the potential of plasma glutamine as a marker for overtraining.

Main Methods:

  • Review of existing literature on glutamine metabolism and its changes during various physiological and pathological conditions.

Related Experiment Videos

  • Analysis of studies reporting plasma glutamine concentrations in athletes following different exercise intensities and durations.
  • Comparison of glutamine levels in overtrained athletes versus healthy controls.

    • Main Results:

    • Prolonged exercise and catabolic stress significantly reduce plasma glutamine levels.
    • Overtrained athletes exhibit lower resting plasma glutamine levels compared to active healthy individuals.
    • Acute, high-intensity exercise may not significantly alter plasma glutamine levels, or may cause temporary elevation.

    Conclusions:

    • Increased gluconeogenesis and tissue glutamine uptake contribute to plasma glutamine depletion during catabolic stress.
    • Persistent low glutamine levels due to heavy training may necessitate extended recovery periods.
    • Plasma glutamine levels are influenced by multiple factors, requiring careful consideration for its use as an overtraining marker.