Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immobility responses in Lurcher mutant mice

R Lalonde1

  • 1Université de Rouen, Faculté des Sciences, Mont-Saint-Alignan, France. lalonde@epeire.univ-rouen.fr

Behavior Genetics
|November 6, 1998
PubMed
Summary

Lurcher mutant mice exhibit impaired inhibitory mechanisms in swimming and locomotion, showing increased activity and reduced immobility. However, they can learn to improve motor coordination in specific tasks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corticosterone effects on postnatal cerebellar development in mice.

Neurochemistry international·2023
Same author

Argon plasma coagulation treatment of anal high-grade squamous intraepithelial lesions in men who have sex with men living with HIV: results of a 2-year prospective pilot study.

HIV medicine·2017
Same author

The future is now: model-based clinical trial design for Alzheimer's disease.

Clinical pharmacology and therapeutics·2015
Same author

Behavioral differentiation of mice exposed to a water tank social interaction test.

Behavioural processes·2014
Same author

Behavioral and neurochemical effects of dietary methyl donor deficiency combined with unpredictable chronic mild stress in rats.

Behavioural brain research·2013
Same author

Neurobehavioral performances and brain regional metabolism in Dab1(scm) (scrambler) mutant mice.

Behavioural brain research·2013

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Genetics

Background:

  • Lurcher mutant mice display cerebellar degeneration, impacting motor control and behavior.
  • Understanding inhibitory mechanisms is crucial for comprehending neurological disorders.

Purpose of the Study:

  • To investigate the specific deficits in inhibitory control in Lurcher mutant mice.
  • To differentiate between motor coordination impairments and inhibitory control failures.

Main Methods:

  • Behavioral testing of Lurcher mutant mice and wild-type littermate controls.
  • Assessing immobility, activity levels, and motor coordination in various tasks (swimming, horizontal/inclined board, inclined grid, dorsal immobility, unstable platform).

Main Results:

  • Lurcher mutants showed reduced immobility during swimming and increased activity on a horizontal but not inclined board.
  • No significant differences were observed in inclined grid or dorsal immobility tests.
  • Impaired performance on an unstable platform motor coordination test, but learning and response withholding were intact.

Conclusions:

  • Lurcher mutants have specific defects in inhibitory mechanisms related to swimming and locomotion.
  • These deficits are distinct from general motor coordination impairments and can be task-specific.
  • The study highlights the complex nature of inhibitory control and its disruption in neurological mutants.

Related Experiment Videos