Related Experiment Video

Updated: Jul 22, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

[Cholestatic-type hepatitis in childhood]

A Molina Merino1, F Martínez-Huguet, M T Asensi Monzó

  • 1Servicio de Pediatría, Hospital Clínico Universitario, Valencia.

Anales Espanoles De Pediatria
|November 6, 1998
PubMed

Insights

Cholestatic hepatitis in children is rare, occurring in 3.45% of acute hepatitis cases. While often caused by hepatitis A or B viruses, it generally has a good prognosis, with recovery within 8 weeks.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Infectious Diseases

Context:

  • Cholestatic hepatitis is a less common presentation of acute hepatitis in children.
  • Understanding its characteristics is crucial for diagnosis and management.

Purpose:

  • To determine the incidence, causes, clinical course, and outcomes of cholestatic hepatitis in pediatric patients.
  • To analyze the clinical and biochemical profiles of children with cholestatic hepatitis.

Summary:

  • This retrospective study identified 5 cases (3.45%) of cholestatic hepatitis among 145 hospitalized children with acute hepatitis.
  • Hepatitis A virus (3 cases) and hepatitis B virus (1 case) were identified etiologies, with one case positive for smooth muscle autoantibodies (SMA).
  • Clinical presentation included cholestatic symptoms and elevated liver enzymes; prognosis was generally favorable, resolving within 8 weeks, except for one case with subacute hepatocellular insufficiency.

Impact:

  • Highlights cholestatic hepatitis as an infrequent but significant diagnosis in pediatric acute hepatitis.
  • Provides insights into the viral and autoimmune etiologies of this condition.
  • Emphasizes the generally favorable prognosis, guiding clinical expectations and treatment strategies.
Abstract

More Related Videos

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults04:14

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Published on: February 28, 2025

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...