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Related Experiment Videos

Ferrous sulphate interacts with captopril

J P Schaefer1, Y Tam, B B Hasinoff

  • 1Department of Medicine, Faculty of Medicine, The University of Calgary, Alberta, Canada.

British Journal of Clinical Pharmacology
|November 6, 1998
PubMed
Summary
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Iron supplements significantly reduce the absorption of the medication captopril. This interaction, likely due to a chemical reaction in the stomach, may affect treatment efficacy when these drugs are taken together.

Area of Science:

  • Pharmacokinetics
  • Drug Interactions
  • Gastrointestinal Absorption

Background:

  • Captopril is an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure.
  • Iron supplements are commonly used to treat iron-deficiency anemia.
  • Potential interactions between medications and supplements can impact therapeutic outcomes.

Purpose of the Study:

  • To investigate the potential for iron to bind with captopril.
  • To assess the impact of iron co-administration on captopril absorption in healthy volunteers.

Main Methods:

  • In vitro experiments to assess iron-captopril binding.
  • A randomized, double-blind, placebo-controlled, cross-over study in seven healthy volunteers.
  • Captopril (25 mg) was co-ingested with ferrous sulfate (300 mg) or placebo.

Related Experiment Videos

  • Plasma captopril levels and blood pressure were monitored over 12 hours.

    • Main Results:

    • Co-administration of ferrous sulfate and captopril decreased unconjugated plasma captopril area under the curve (AUC) by 37% (P=0.03).
    • No significant changes were observed in Cmax or Tmax for unconjugated captopril.
    • In vitro, ferric chloride formed a complex with captopril, leading to a precipitate identified as captopril disulphide dimer.

    Conclusions:

    • Iron significantly reduces the absorption of unconjugated captopril, likely due to a chemical interaction in the gastrointestinal tract.
    • Caution is advised when prescribing captopril and iron salts concurrently.
    • Further studies may be needed to evaluate the clinical significance of this interaction.