Reversible pitch perception deficit due to carbamazepine

Area of Science:

• Neuroscience
• Pharmacology
• Otolaryngology

Background:

• Carbamazepine (CBZ) is a widely prescribed antiepileptic and neurological medication.
• Adverse effects of CBZ are generally well-documented, but auditory disturbances are rarely reported.
• Abnormal pitch perception is an uncommon neurological symptom associated with certain medications.

Observation:

• An 18-year-old female patient initiated CBZ treatment for epilepsy.
• Following treatment initiation, the patient reported a subjective lowering of perceived auditory pitch.
• This auditory disturbance was directly linked to the commencement of CBZ therapy.

Findings:

• The case report documents a rare instance of CBZ-induced abnormal pitch perception.
• A review of existing literature identified other cases of CBZ-associated auditory disturbances, specifically concerning pitch perception.
• This suggests a potential, albeit infrequent, ototoxic effect of carbamazepine.

Implications:

• Clinicians should be aware of the potential for CBZ to cause auditory disturbances, including altered pitch perception.
• Early recognition and reporting of such symptoms are crucial for patient management and understanding drug side effects.
• Further research may be warranted to elucidate the mechanisms behind CBZ-induced auditory changes.