Some neoplasms and some hamartomatous syndromes: genetic considerations
1Department of Oral & Maxillofacial Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada.
Abstract:
This is the first of three articles on modern genetic concepts of a number of syndromes and disorders. About 1% of cancer mutations arise in the germline and produce a variety of neoplasms and hamartomatous syndromes. However, upward of 10-15% of all cancers have a major inherited component, although many of these are still enigmatic. The genetic basis is presented and following a review of many neoplasms and hamartomatous syndromes, the RET proto-oncogene is discussed as an example.
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