Effects of zinc supplementation during chelating agent administration in cadmium intoxication in rats

The concomitant administration of zinc during chelation of cadmium (Cd) with meso-2,3-dimercaptosuccinic acid (DMSA) or calcium trisodium diethylenetriamine penta-acetic acid (DTPA) was investigated in male rats subchronically exposed to Cd. The results suggest that the administration of zinc alone after cadmium exposure does not elicit any protective effects. However, when supplemented during treatment with DTPA it produced a significant turnover in the altered biochemical variables and a depletion of Cd concentration in liver and kidneys. Cadmium-induced elevated hepatic metallothionein (MT) contents remained practically unaltered on Zn-DTPA administration, but there was a significant increase in renal MT levels compared to rats administered Cd-DTPA or Cd alone.