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Localization of the Locus Coeruleus in the Mouse Brain
Published on: March 7, 2019
Quantitative trait loci implicated in corpus callosum midsagittal area in mice
I L Roy1, F Perez-Diaz, P Roubertoux
1UPR CNRS 9074, Génétique, Neurogénétique, Comportement, Institut de Transgénose, CNRS, 3 B Rue de la Ferollerie, 45071, Orléans Cedex 02, France.
Brain Research
|November 7, 1998
Summary
The midsagittal area of the corpus callosum is smaller in NZB/BlNJ mice compared to C57BL/6By mice. Quantitative trait loci (QTL) mapping identified two interacting loci, CCrSQTL1 and CCrSQTL2, influencing this trait.
Area of Science:
- Neurogenetics
- Quantitative Trait Loci (QTL) analysis
- Mouse genetics
Background:
- The midsagittal area of the corpus callosum, as a percentage of hemispheric surface, differs between mouse strains.
- NZB/BlNJ mice exhibit a smaller corpus callosum area compared to C57BL/6By mice.
Purpose of the Study:
- To identify the genetic loci responsible for the variation in midsagittal corpus callosum area between NZB/BlNJ and C57BL/6By mouse strains.
- To investigate potential interactions between these genetic loci.
Main Methods:
- Quantitative trait loci (QTL) mapping was performed on 284 F2 intercross mice derived from NZB/BlNJ and C57BL/6By strains.
- Analysis focused on the midsagittal area of the corpus callosum as a percentage of the hemispheric surface.
Main Results:
- Two significant quantitative trait loci (QTL) were identified and named CCrSQTL1 on chromosome 1 and CCrSQTL2 on chromosome 4.
- CCrSQTL1 was mapped to 87 centimorgans and CCrSQTL2 to 67 centimorgans from the centromere.
- A significant interaction between CCrSQTL1 and CCrSQTL2 was detected, collectively explaining 25% of the observed genetic variance.
Conclusions:
- The genetic architecture of midsagittal corpus callosum area involves at least two interacting loci.
- These findings provide a foundation for further molecular studies to elucidate the specific genes and mechanisms underlying corpus callosum development and variation.
