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Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1
M A McIlhatton1, P Bremner, M F McMullin
1Department of Haematology, Institute of Clinical Science, The Queen's University of Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UK.
Biochimica Et Biophysica Acta
|November 7, 1998
Abstract:
Homeobox gene expression was examined in the erythroleukaemic cell line TF-1. Expression of a number of HOX A, B and C genes, including HOX A7 was detected. Expression of this gene has not previously been reported in erythroleukaemic cell lines. A 2.1 kb full length cDNA of the HOX A7 gene was cloned. The predicted amino acid sequence C-terminal to the homeodomain consists of an alanine-rich region and a strongly negatively charged domain consisting entirely of aspartic and glutamic acid residues.