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[The immunogenicity of the Heberbiovac-HB vaccine in children]

M Díaz González1, A Chiang Macía, D Díaz Acosta

  • 1Instituto de Medicina Tropical Pedro Kourí.

Revista Cubana De Medicina Tropical
|January 1, 1996
PubMed

Insights

The Cuban recombinant hepatitis B vaccine (HBV) is highly immunogenic in children under 15. This vaccine demonstrates 100% seroconversion and protective antibody titers, making it recommendable for HBV protection.

Area of Science:

  • Immunology
  • Vaccinology
  • Public Health

Background:

  • Hepatitis B virus (HBV) infection is a significant global health concern.
  • Effective vaccination strategies are crucial for preventing HBV transmission, especially in pediatric populations.
  • Recombinant vaccines offer a safe and effective approach to hepatitis B immunization.

Purpose of the Study:

  • To evaluate the immunogenicity of a Cuban recombinant hepatitis B vaccine in children under 15 years of age.
  • To assess seroconversion rates and protective antibody titers following vaccination.
  • To compare vaccine response across different age groups within the pediatric cohort.

Main Methods:

  • A cohort of children under 15 received a 10 µg dose of the Cuban recombinant hepatitis B vaccine following a 0, 1, and 6-month schedule.
  • Immunogenicity was assessed at 2, 7, and 12 months post-vaccination.
  • Key metrics included seroconversion rates, antibody titers (UI/L), and geometric mean titers (GMT).

Main Results:

  • The vaccine achieved 100% seroconversion in all vaccinated children.
  • High percentages of participants attained protective antibody titers (>100 UI/L) at various time points (65.9% at 60 days, 100% at 210 days, 83.5% at 360 days).
  • Preschool and school-aged children showed significantly higher antibody responses compared to those over 10 years old (p < 0.05).

Conclusions:

  • The Cuban recombinant hepatitis B vaccine exhibits high immunogenicity and induces protective antibody levels in children under 15.
  • The vaccine is well-tolerated and effective in preventing hepatitis B virus infection across the studied pediatric age groups.
  • The findings support the recommendation of this vaccine for the protection of children against hepatitis B.

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