Biomechanical behavior of the arterial wall and its numerical characterization
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Updated: Oct 27, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
G A Holzapfel1, H W Weizsäcker
1Institut für Baustatik-Computational Biomechanics, Technische Universität Graz, Austria. gerhard.holzapfel@biomech.tugraz.ac.at
Abstract:
This paper presents the biomechanical behavior of two types of rat arteries under the passive state of the vascular smooth muscles. The hyperelastic, highly nonlinear, incompressible and orthotropic stress-strain behavior of arteries is described by adopting a classical material model of the exponential type and a 'biphasic' one, recently proposed by the authors. In order to obtain the fundamental relations for a computer simulation the theoretical continuum-mechanical background is briefly reviewed in a compact manner as well. By using the new material model the study shows a significant improvement in approaching the experimental stress-strain data within the entire pressure domain (from 0 up to 200 mm Hg) and for various levels of prestretch encompassing physiological pressures and the individual in vivo axial prestretches.
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