[Vasoactive properties of various fragments of human alpha-calcitonin gene-related peptide]
V A Akopian1, N V Balashov, S V Burov
1I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Acad. Sci., St. Petersburg, Russia.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|November 7, 1998
Abstract:
Effects of some fragments of alpha-calcitonine gene-related peptide (alpha-CGRP) on the collector lymphatic vessels of the rat small intestine mesenterium, were studied. All the fragments excepting alpha-CGRP (21-24) and (21-31) activate motility of the lymphatic vessels enhancing phasic contractions of the walls. Presence of aminoacid residuals in the 20-29 area is "critical" for realising vasoactive properties by these fragments.
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