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Updated: Oct 2, 2026
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Cellular DNA contact and its correlation with histopathological prognostic parameters in carcinoma of the breast
S Chaturvedi1, S Singh, H D Khanna
1Department of Pathology, Banaras Hindu University, Varanasi.
Abstract:
Present study has given an insight in to the value of the DNA in relation to other morphometrics. Breast cancer shows variability in clinical course in the same clinical stage. Cellular DNA content is an important prognostic parameter. Tumour tissue DNA content is correlated with known histopathological prognostic feature assessing its significance as prognostic parameter in 25 cases of carcinoma breast. The findings showed that cellular DNA content ranged between 1.5-5.08 ug/mg in cancer breast tissue with an average of 2.54 ug/mg as compared to an average of 1.34 ug/mg in normal breast tissue. The DNA content was higher in combined pattern, in poorly differentiated duct carcinoma and in patients with positive lymph node metastasis. No consistent relationship could be seen between cellular DNA and desmoplasia and lymphoreticular response in and around tumour.
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