Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preliminary experience with frameless stereotactic radiotherapy

J M Buatti1, F J Bova, W A Friedman

  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville 32610, USA.

International Journal of Radiation Oncology, Biology, Physics
|November 7, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iron-based biomarkers for personalizing pharmacological ascorbate therapy in glioblastoma: insights from a phase 2 clinical trial.

Journal of neuro-oncology·2024
Same author

Magnetite nanoparticles as a kinetically favorable source of iron to enhance GBM response to chemoradiosensitization with pharmacological ascorbate.

Redox biology·2023
Same author

Avasopasem manganese (GC4419) protects against cisplatin-induced chronic kidney disease: An exploratory analysis of renal metrics from a randomized phase 2b clinical trial in head and neck cancer patients.

Redox biology·2023
Same author

Design and characterization of a prototype tertiary device for proton beam stereotactic radiosurgery.

Biomedical physics & engineering express·2021
Same author

The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development.

Blood advances·2020
Same author

Proton vs Hyperarc™ radiosurgery: A planning comparison.

Journal of applied clinical medical physics·2020

This study shows that a new frameless stereotactic radiotherapy system provides highly accurate and practical treatments for brain tumors. Initial clinical experience demonstrated minimal side effects and excellent precision, making it a promising tool for neuro-oncology.

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Medical Physics

Background:

  • Stereotactic radiotherapy (SRT) offers precise radiation delivery for brain tumors.
  • Advancements in frameless systems aim to improve accuracy and patient comfort.
  • The University of Florida developed a novel high-precision frameless stereotactic radiotherapy system.

Purpose of the Study:

  • To evaluate the initial clinical experience and performance of a new frameless stereotactic radiotherapy system.
  • To assess treatment accuracy, reproducibility, and clinical outcomes.
  • To determine the feasibility and practicality of this novel SRT approach.

Main Methods:

  • Sixty patients (age 2-82) received 1426 treatments using the frameless system.
  • Tumors treated included meningiomas, astrocytomas, germinomas, and craniopharyngiomas.

Related Experiment Videos

  • Treatment reproducibility was measured using infrared light-emitting diodes (IRLEDs) and compared to a stereotactic radiosurgery reference system, with a maximum tolerated misalignment of 0.3 mm and 0.3 degrees.

    • Main Results:

    • Mean follow-up was 11 months; only 3 patients experienced recurrence.
    • Acute side effects were minimal; 4/11 low-grade astrocytoma patients had transient cerebral edema.
    • Treatment accuracy exceeded expectations, with translational errors <0.10 mm and rotational errors <0.06 degrees. Daily treatments averaged 15 minutes.

    Conclusions:

    • Initial clinical experience with the frameless SRT system and its infrared guidance was positive.
    • The system demonstrated superior treatment accuracy and practicality.
    • Evolving patient selection and treatment strategies show promise for this advanced radiotherapy approach.