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Updated: Oct 27, 2026
Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential
C I Friedman1, D B Seifer, E A Kennard
1Department of Obstetrics and Gynecology, The Ohio State University, Columbus 43210, USA.
Objective:
To evaluate whether differences in follicular fluid vascular endothelial growth factor (FF VEGF) concentrations are observed between women achieving a clinical pregnancy and those failing to conceive.
Design:
Retrospective chart review and analysis of FF VEGF concentrations.
Setting:
University teaching center.
Patient(S):
Fifty-seven women < or =42 years of age undergoing follicular aspiration in preparation for IVF or GIFT.
Intervention(S):
Analysis of FF VEGF concentrations and chart review of a single IVF or GIFT cycle.
Main Outcome Measure(S):
Follicular fluid VEGF concentrations, clinical pregnancy rate, age, ampules of gonadotropins used, oocytes retrieved, peak estradiol serum concentrations, day 3 FSH levels, and fertilization rate.
Result(S):
Women who did not conceive had higher FF VEGF concentrations than women achieving a clinical pregnancy (4.409 + 2,387 versus 2.793 +/- 1,180 pg/mL: P < .001). A negative correlation was observed between FF VEGF concentrations and peak estradiol levels and number of oocytes retrieved. A positive correlation was found for FF VEGF and patient's age and ampules of gonadotropins used.
Conclusion(S):
Elevated FF VEGF concentrations are associated with poor conception rates after IVF or GIFT.
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