Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemorheological changes in nephrotic syndrome

S Sahu1, K Nageswari, R Banerjee

  • 1School of Biomedical Engineering, Indian Institute of Technology, Powai, Bombay.

Clinical Hemorheology and Microcirculation
|November 7, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Processing-driven chemical ordering and its effect on magnetic properties in a high entropy alloy.

Faraday discussions·2025
Same author

Does childhood TB or pneumonia impact COPD or asthma in adulthood?

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
Same author

Lisfranc Injury: a Comprehensive Analysis of LongTerm Outcomes - the Oswestry Experience.

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2025
Same author

A Systematic Review and Meta-Analysis of the Outcomes of Reconstruction with Vascularised vs Non-Vascularised Bone Graft after Surgical Resection of Primary Malignant and Non-Malignant Bone Tumors.

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2024
Same author

A Systemic Review of Primary Malignant Long Bone Tumors in Children and Adolescents.

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2024
Same author

Viscosupplementation with High Molecular Weight Hyaluronic Acid for Hip Osteoarthritis: a Systematic Review and Meta-Analysis of Randomised Control Trials of the Efficacy on Pain, Functional Disability, and the Occurrence of Adverse Events.

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2024

Childhood nephrotic syndrome alters hemorheological parameters, increasing blood viscosity during relapse. These changes, linked to serum biochemistry, may help predict relapse risk.

Area of Science:

  • Pediatric Nephrology
  • Hemodynamics
  • Clinical Biochemistry

Background:

  • Childhood nephrotic syndrome (CNS) is a complex renal disease.
  • Understanding hemorheological alterations in CNS is crucial for management.
  • Previous studies have indicated potential links between blood fluidity and disease activity.

Purpose of the Study:

  • To investigate hemorheological parameters in children with nephrotic syndrome during relapse and remission.
  • To compare these parameters with those of healthy children.
  • To explore the role of serum/plasma biochemistry in influencing blood fluidity.

Main Methods:

  • Comparative study involving 120 children (60 with CNS in relapse, 60 in remission) and 120 healthy controls.
  • Measurement of plasma viscosity, red cell rigidity, and whole blood viscosity.

Related Experiment Videos

  • Analysis of serum/plasma biochemistry including fibrinogen, cholesterol, triglycerides, total protein, and albumin.
  • Statistical analysis using t-test with a significance level of p = 0.05.

    • Main Results:

    • During relapse, significantly deranged hemorheological parameters were observed compared to remission.
    • Elevated plasma viscosity, red cell rigidity, and whole blood viscosity were noted during relapse.
    • High fibrinogen, cholesterol, and triglyceride levels correlated with increased blood viscosity.
    • Reduced total protein and albumin levels were significant during relapse compared to remission.

    Conclusions:

    • Hemorheological parameters are significantly altered in childhood nephrotic syndrome, particularly during relapse.
    • Serum biochemistry, including lipids and proteins, plays a key role in modulating blood fluidity.
    • Hemorheological profiling may aid in early detection of relapse-prone cases and serve as a prognostic indicator.