Original research: the relationship between dialysis adequacy and quality of life: a report of a pilot study

Adequacy of dialysis, as measured by urea kinetic modelling (UKM), is considered an extremely important clinical outcome for all dialysis programs. While improving adequacy has been clearly linked to decreased mortality among hemodialysis patients, the relationship between adequacy and patients' quality of life remains less clear. Patients with higher Kt/Vs live longer, but do they live better? This paper describes the results of a pilot study designed to examine the relationship between adequacy of hemodialysis and the patient's perceived quality of life. This time series study employed a convenience sampling technique consisting of all willing new patients to join an in-centre hemodialysis program in a six-month period. The adequacy of each new patient's dialysis prescription was determined by analyzing urea kinetics at one and three months following the commencement of therapy. Dialysis prescription changes were made by the interdisciplinary team, as necessary and where possible, to achieve a minimum Kt/V of 1.2. Each new patient's quality of life was measured at the same time intervals, that is, one and three months using two instruments. The first, the SF36 is a generic 36-item instrument designed to measure a range of functioning and well-being. The second, the Kidney Disease Questionnaire (KDQ) is a disease-specific quality of life instrument designed for use with chronic hemodialysis patients. Results showed that both adequacy and quality of life scores improved from one to three months. There are, however, too many competing explanations to assume a relationship between the two variables. Future analysis with a larger sample will employ an analysis of covariance to look for relationships.