Related Experiment Video
Updated: Oct 27, 2026

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
Published on: April 19, 2024
The effect of manual lung hyperinflation and postural drainage on pulmonary complications in mechanically ventilated
G Ntoumenopoulos1, A Gild, D J Cooper
1Trauma Intensive Care Unit, Alfred Hospital, Melbourne, Victoria.
Abstract:
This study questioned whether manual lung hyperinflation (MHI) and postural drainage reduced the incidence of nosocomial pneumonia or improved other outcome variables in mechanically ventilated trauma patients. Patients were withdrawn from the study if they developed nosocomial pneumonia according to a predetermined definition or on the clinical suspicion of nosocomial pneumonia by the attending intensivist. Of the 46 patients who fulfilled all the inclusion criteria and were enrolled into the study, 22 patients were randomized to group A (physiotherapy) and 24 patients to group B (control group). Twice as many patients were withdrawn in group B (8/24) compared with group A (4/22), although the differences were not statistically significant, [X2(1, 1) = 1.36, P = 0.24]. The length of time receiving mechanical ventilation and in the ICU was similar between the two groups and there were no differences in pulmonary dysfunction ("worst" daily PaO2/FiO2 ratio) between the two groups. There were no ICU deaths in either group. Physiotherapy as used in this study was not associated with a reduced incidence of nosocomial pneumonia based on standard clinical criteria. Nevertheless the trend to more frequent nosocomial pneumonia in the control patients suggests that a larger study in more severely injured patients with stricter clinical criteria for the definition of nosocomial pneumonia is indicated.
Insights
Manual lung hyperinflation and postural drainage did not significantly reduce nosocomial pneumonia in ventilated trauma patients. A trend suggested potential benefits, warranting further investigation in larger studies.
Area of Science:
- Critical Care Medicine
- Respiratory Therapy
- Trauma Surgery
Background:
- Nosocomial pneumonia is a significant complication in mechanically ventilated trauma patients.
- Effective preventative strategies are crucial for improving outcomes in this vulnerable population.
Purpose of the Study:
- To evaluate the efficacy of manual lung hyperinflation (MHI) and postural drainage in reducing nosocomial pneumonia incidence.
- To assess the impact of these physiotherapy techniques on other outcome variables in mechanically ventilated trauma patients.
Main Methods:
- A randomized controlled study involving 46 mechanically ventilated trauma patients.
- Group A received physiotherapy (MHI and postural drainage); Group B served as the control.
- Patients were withdrawn upon diagnosis or suspicion of nosocomial pneumonia.
Main Results:
- No statistically significant difference in nosocomial pneumonia incidence between the physiotherapy and control groups.
- Similar durations of mechanical ventilation and ICU stay in both groups.
- No significant differences in pulmonary function (PaO2/FiO2 ratio) or ICU mortality were observed.
Conclusions:
- Physiotherapy, as implemented, did not significantly reduce nosocomial pneumonia in this patient cohort.
- A trend suggested a higher incidence in the control group, indicating a need for larger studies.
- Further research with stricter diagnostic criteria in severely injured patients is recommended.
Related Concept Videos
Pneumothorax II: Pathophysiology
Pneumothorax-II
Clinical Manifestations:
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Atelectasis II: Pathophysiology
Flail Chest-II
Assessment:
1. Clinical Evaluation:
History:
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...