Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Energy-dependent chromatin remodelers: complex complexes and their components

A N Imbalzano1

  • 1Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA.

Critical Reviews in Eukaryotic Gene Expression
|November 10, 1998
PubMed
Summary

ATP-dependent chromatin remodelers are essential protein complexes that modify chromatin structure. These conserved complexes play diverse roles in cellular processes, including gene transcription, cell growth, and development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.

Oncogene·2024
Same author

Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer.

Genes, chromosomes & cancer·2019
Same author

Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.

Oncogene·2013
Same author

The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells.

Oncogene·2009
Same author

Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivo.

Journal of molecular endocrinology·2006
Same author

MyoD can induce cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes.

The Journal of biological chemistry·2001

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Chromatin structure is dynamically regulated by various factors in response to cellular signals.
  • ATP-dependent nucleosome remodeling complexes are a key class of factors mediating these structural changes.

Purpose of the Study:

  • To investigate the role and conserved functions of ATP-dependent chromatin remodelers.
  • To highlight their involvement in diverse cellular processes.

Main Methods:

  • Genetic and biochemical evidence was used to study these complexes.
  • Analysis of conserved multisubunit complexes from yeast to mammals.

Main Results:

  • ATP-dependent chromatin remodelers hydrolyze ATP to rearrange chromatin structure.

Related Experiment Videos

  • These complexes are implicated in nucleosome deposition, assembly, and transcriptional activation.
  • Individual components regulate cell growth, cell cycle, development, and differentiation.

    • Conclusions:

    • ATP-dependent chromatin remodelers are conserved and functionally diverse.
    • Their regulation of chromatin structure is critical for numerous cellular functions and metabolism.