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Updated: Aug 19, 2026
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Prognostic factors and predictive tables of non-localized prostate cancer that exclude therapy by radical
H Villavicencio Mavrich1, F Millán Rodríguez, G Chéchile Toniolo
1Servicio de Urología, Fundación Puígvert, Barcelona.
Objective:
To know the predictive factors of the no localized prostatic cancer (NLPC) with the intention of improving the indications of the radical prostatectomy.
Methods:
A longitudinal, observational, analytic and retrospective study is made with our first 216 radical prostatectomies. A multivariate analysis by logistic regression has been made. A predictive evacuation with the odds ratio of the risc factors, a ROC curve and predictive tables of the NLPC are obtained.
Results:
Clinical stage, PSA and Gleason are predictive factors of the NLPC. The predictive evacuation with a cut point of probability p = 0.5 has a specificity of 81%, a sensibility of 70% and global diagnostic capacity of 75%. NLCP odds ratio are: Gleason 5,6,7/Gleason 2,3,4 = 2.6, Gleason 8,9,10/Gleason 5,6,7 = 3, Gleason 8,9,10/Gleason 2,3,4 = 7.6, T2/T1 = 2, T3/T2 = 5, T3/T1 = 10 and PSA = 1. After the study of the predictive tables it can be concluded that T3, Gleason > = 8 and PSA > = 30 have a very high NLPC probability.
Conclusions:
PSA, Gleason and clinical stage are NLPC predictive factors. Predictive tables to know the NLPC probability by these 3 factors are available.
