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[Menopause. Hormone substitution therapy and prevention of cardiovascular risk]
R Grio1, A Cellura, M Porpiglia
1Dipartimento di Scienze Ginecologiche Ostetriche, Università degli Studi, Torino.
Background And Aims:
Cardiovascular disease is the major cause of death in over 60-year-old women. The mean age of onset is about 10 years later in women compared to men, a difference which can be explained by the end of physiological estrogen production in menopause.
Methods:
The authors treated a group of 68 menopausal patients with HRT for a period of 5 years.
Results:
A series of positive effects emerged from the study which were potentially capable of preventing ischemic cardiopathy.
Conclusions:
The authors reached the conclusion that--owing to its beneficial effects on lipid and glucose metabolism, as well as on coagulation factors and arterial pressure--HRT is able to prevent cardiovascular disease, reducing the risk of infarction by between 20 and 50%.