Related Experiment Videos
Thyroid function during and after cardiopulmonary bypass in children
K Saatvedt1, H Lindberg, O R Geiran
1Surgical Department A, Rikshospitalet, Oslo, Norway.
Insights
Pediatric thyroid function, including triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH), significantly decreases after cardiopulmonary bypass (CPB) during heart surgery.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Surgery
- Thyroid Physiology
Background:
- Cardiopulmonary bypass (CPB) is a critical procedure in pediatric cardiac surgery.
- Thyroid hormone levels can be affected by major surgical stress and physiological changes.
Purpose of the Study:
- To investigate alterations in thyroid function during and after CPB in children.
- To quantify changes in key thyroid hormones and TSH levels.
Main Methods:
- Prospective study involving 10 children undergoing elective congenital heart defect surgery.
- Measurement of triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) at multiple time points: preoperatively, during CPB, and up to 48 hours postoperatively.
Main Results:
- Significant decrease in T3 and T4 levels observed 24 hours postoperatively.
- Transient increase in free thyroxine (FT4) noted early during CPB.
- Significant reduction in TSH levels 24 hours after surgery.
Conclusions:
- Pediatric patients undergoing open-heart surgery with CPB experience significant depression of T3, T4, and TSH levels.
- Thyroid function monitoring is crucial in the perioperative period for children undergoing CPB.
Background:
The aim of the study was to elucidate the changes in thyroid function during and after cardiopulmonary bypass (CPB) in children.
Methods:
Triiodothronine (T3), thyroxine (T4), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were determined preoperatively, at specific times throughout CPB, and serially up to 48 h postoperatively, in 10 children (median age 35, range 23-68 months) undergoing elective surgery for congenital heart disease.
Results:
T3 decreased from 2.01 +/- 0.08 preoperatively to 0.94 +/- 0.10 nmol/l 24 h postoperatively (P < 0.05). T4 levels followed a pattern similar to changes in T3. FT4 increased from 17.4 +/- 0.7 preoperatively to 30.0 +/- 0.4 pmol/l after 30 min of CPB (P < 0.05). TSH decreased from 2.44 +/- 0.43 preoperatively to 0.93 +/- 0.21 24 h postoperatively (P < 0.05).
Conclusion:
T3, T4 and TSH are significantly depressed after open heart surgery in children.