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Related Experiment Videos

Hydroxyethyl starch impairs in vitro coagulation

T T Niemi1, A H Kuitunen

  • 1Department of Anaesthesiology, Helsinki University Central Hospital, Finland.

Acta Anaesthesiologica Scandinavica
|November 11, 1998
PubMed
Summary
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Hydroxyethyl starch (HES) solutions impair blood coagulation, with higher molecular weight HES showing a more detrimental effect. Ringer’s acetate and albumin initially improved coagulability but decreased it at higher concentrations.

Area of Science:

  • Anesthesiology
  • Hematology
  • Pharmacology

Background:

  • Artificial colloids, such as hydroxyethyl starch (HES) solutions, can significantly impact haemostasis.
  • Previous research suggests potential detrimental effects of HES on the body's blood clotting mechanisms.

Purpose of the Study:

  • To investigate the in vitro effects of various hydroxyethyl starch (HES) solutions on blood coagulation.
  • To compare the impact of different molecular weights and concentrations of HES with Ringer's acetate and albumin on haemostatic parameters.

Main Methods:

  • A crossover study involving ten volunteers where venous blood samples were collected.
  • Addition of Ringer's acetate, low molecular weight HES (120,000 MW, 200,000 MW), high molecular weight HES (400,000 MW), or albumin to blood samples at 20% and 50% concentrations.

Related Experiment Videos

  • Analysis of coagulation parameters using thrombelastography (TEG).

    • Main Results:

    • All tested HES solutions at 20% concentration reduced clot formation rate (alpha-angle and maximum amplitude).
    • Ringer's acetate and albumin enhanced coagulability at 20% concentration, while all solutions prolonged coagulation time (r + K) at 50% concentration.
    • Higher molecular weight HES (400,000 MW) showed a more significant prolongation of coagulation time compared to lower molecular weight HES at 50% dilution.

    Conclusions:

    • HES solutions exert an adverse effect on in vitro coagulation measures at both 20% and 50% concentrations.
    • High molecular weight HES demonstrates a more pronounced impairment of coagulation compared to low molecular weight HES at 50% dilution.
    • Ringer's acetate and albumin induced a hypercoagulable state at 20% but decreased coagulability at 50% concentration.