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Anger attacks in depression

M Fava1, J F Rosenbaum

  • 1Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA.

Depression and Anxiety
|November 11, 1998
PubMed
Summary
This summary is machine-generated.

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Antidepressant treatment effectively reduces anger attacks in approximately two-thirds of patients with unipolar depression. These medications are safe and well-tolerated, with low rates of new anger attacks emerging post-treatment.

Area of Science:

  • Psychiatry
  • Neuroscience

Background:

  • Anger, hostility, and irritability are common in unipolar depressive disorders.
  • About one-third of depressed outpatients experience "anger attacks," characterized by sudden anger and autonomic symptoms.
  • Depressed patients with anger attacks exhibit higher anxiety, hostility, and personality disorder comorbidities.

Purpose of the Study:

  • To evaluate the safety and efficacy of antidepressant treatment for anger attacks in patients with unipolar depression.
  • To compare the effectiveness of different antidepressants and their rates of anger attack emergence.

Main Methods:

  • Review of studies on antidepressant treatment for anger attacks in depression.
  • Analysis of remission rates for anger attacks with specific antidepressants (fluoxetine, sertraline, imipramine).

Related Experiment Videos

  • Comparison of the emergence rates of anger attacks during and after antidepressant treatment versus placebo.

    • Main Results:

    • Antidepressant treatment leads to the disappearance of anger attacks in 53-71% of depressed outpatients.
    • Emergence rates of anger attacks with fluoxetine (6-7%), sertraline (8%), and imipramine (10%) are comparable and lower than placebo (20%).
    • Antidepressants targeting the central serotonergic system may be particularly effective.

    Conclusions:

    • Antidepressant therapy is a safe and effective treatment for anger attacks associated with unipolar depression.
    • Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants show significant efficacy in managing anger attacks.
    • Further research into the role of serotonergic pathways in treating anger attacks is warranted.