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Related Experiment Videos

Delayed hypersensitivity to diclofenac: a report on two cases

A Romano1, D Quaratino, G Papa

  • 1Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, C.I. Columbus, Italy.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|November 11, 1998
PubMed
Summary

Diclofenac can cause delayed hypersensitivity skin reactions. Delayed-reading intradermal and patch tests effectively diagnose these adverse drug reactions.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Immunology

Background:

  • Skin reactions are known side effects of diclofenac, a nonsteroidal anti-inflammatory drug.
  • However, the specific immunopathogenic mechanisms underlying these reactions are rarely documented.

Observation:

  • Two patients developed maculopapular rashes 48 and 72 hours after starting diclofenac.
  • Skin and patch testing were performed on these individuals.

Findings:

  • Prick and intradermal tests with diclofenac were initially negative but showed an erythematous infiltrate at the intradermal site after 24 hours.
  • Patch tests with diclofenac were positive at both 48 and 72 hours.

Implications:

  • The clinical presentation and test results suggest delayed hypersensitivity to diclofenac.

Related Experiment Videos

  • Delayed-reading intradermal and patch tests appear to be a simple and effective diagnostic method for this type of diclofenac-induced hypersensitivity.