Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumor necrosis factor-alpha levels decrease with anticytokine therapy in patients with myelodysplastic syndromes

S Reza1, V Shetty, S Dar

  • 1Rush Cancer Institute, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612-3515, USA.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|November 11, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Detection of Ultrahigh Energy Emission from Gamma-Ray Binary LS I +61° 303.

Physical review letters·2026
Same author

Evidence of Cosmic-Ray Acceleration up to Sub-PeV Energies in the Supernova Remnant IC 443.

Physical review letters·2026
Same author

Transabdominal preperitoneal (TAPP) versus totally extraperitoneal (TEP) repair for inguinal hernia: a systematic review and meta-analysis.

Annals of the Royal College of Surgeons of England·2026
Same author

Precise Measurement of the Cosmic Ray Helium Spectrum above 0.1 PeV.

Physical review letters·2026
Same author

A REVIEW OF CURRENT CONCEPTS IN THE MANAGEMENT OF BONE DEFECTS IN TRAUMA AND ORTHOPAEDICS.

Georgian medical news·2025
Same author

All-Sky Search for Individual Primordial Black Hole Bursts with LHAASO.

Physical review letters·2025
Same journal

Targeted Inhibition of <i>RPA3</i> Impairs Breast Cancer Progression Through Suppressing TGF-β Signaling Pathway-Mediated Autophagy.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

Translational Analysis of Cytokine SNPs Reveals an Interplay Between Immune Response and Glucose Metabolism Following Mild-to-Moderate COVID-19.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

IL-6-JAK2-STAT3 Signaling Pathway and the Pathogenesis of Chronic Tonsillitis.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

A Stable Reporter Cell Line to Study Respiratory Syncytial Virus NS2-Mediated Inhibition of <i>IFNB</i> Promoter Activation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

Human Macrophages Secrete Both Interferon α and Interferon β Proteins During Infection with <i>Mycobacterium tuberculosis</i>.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

Biochemical Signature in Deciphering the Metastasis-Associated Lung Adenocarcinoma Transcript 1/microRNA-145 Axis and Its Molecular Correlation with Nuclear Factor Kappa Beta/Transforming Growth Factor-Beta and Apoptotic Proteins Expression in Colorectal Cancer.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
See all related articles

Myelodysplastic syndromes (MDS) patients with higher bone marrow Tumor Necrosis Factor-alpha (TNF-alpha) levels responded better to pentoxifylline and ciprofloxacin (PC) therapy. This PC therapy effectively reduced TNF-alpha levels over time.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
  • Elevated levels of pro-inflammatory cytokines, such as Tumor Necrosis Factor-alpha (TNF-alpha), are implicated in MDS pathogenesis.
  • Understanding the role of TNF-alpha in MDS may reveal therapeutic targets.

Purpose of the Study:

  • To investigate the correlation between baseline TNF-alpha levels and treatment response in MDS patients.
  • To evaluate the efficacy of pentoxifylline and ciprofloxacin (PC) therapy, with or without dexamethasone (PCD), in reducing TNF-alpha levels.
  • To assess the impact of PC/PCD therapy on hematologic and cytogenetic parameters in MDS.

Main Methods:

  • Serum and bone marrow (BM) TNF-alpha levels were measured in 43 MDS patients using ELISA and immunohistochemistry, respectively.

Related Experiment Videos

  • Patients received 12 weeks of PC therapy; nonresponders were offered additional dexamethasone (PCD).
  • Hematologic and cytogenetic responses were assessed, and BM TNF-alpha levels were tracked during therapy.

    • Main Results:

    • Eighteen of 43 patients achieved a hematologic or cytogenetic response.
    • Responders exhibited higher baseline BM TNF-alpha levels compared to nonresponders (median 3.5 vs. 2.0).
    • PC therapy significantly reduced BM TNF-alpha levels at 2, 8, and 12 weeks in the overall group; responders showed sustained reduction at 12 weeks.

    Conclusions:

    • Higher baseline BM TNF-alpha levels may predict a better response to PCD therapy in MDS patients.
    • PC/PCD therapy demonstrates sustained efficacy in reducing TNF-alpha levels in MDS.
    • Further research is needed to identify more potent suppressors of pro-apoptotic cytokines in MDS.