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WT1--more than a transcription factor?
1Research Center Karlsruhe, Institute of Genetics, Karlsruhe, Germany. Christoph.englert@igen.fzk.de
Trends in Biochemical Sciences
|November 12, 1998
Abstract:
The Wilms tumor-suppressor gene WT1 was originally identified through its involvement in the development of a pediatric kidney tumor. Recent genetic data show that mutations in the WT1 gene cause a variety of other diseases, and new biochemical evidence suggests that the WT1 protein is not only a transcription factor but might also act at the post-transcriptional level.
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