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[Mitochondrial encephalomyopathies starting in childhood and adolescence]
M Castro-Gago1, M I Novo-Rodríguez, J Eirís-Puñal
1Departamento de Pediatría, Hospital General de Galicia, Complejo Hospitalario Universitario de Santiago de Compostela, SERGAS, España. pdcastro@uscmail.usc.es
Introduction:
In this chapter we carry out a review of the current basic clinical and diagnostic aspects of mitochondrial cytopathies due to deficiencies in the mitochondrial respiratory chain complexes, which appear clinically during childhood and/or adolescence.
Development:
The description has been divided into two groups: mitochondrial cytopathies secondary to alterations of the mitochondrial DNA (mtDNA) and mitochondrial cytopathies secondary to alterations of the nuclear DNA (nDNA).
Conclusions:
We conclude by considering the importance of such conditions at this age.