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[Mitochondrial diseases and stroke]

P Irimia1, A Oliveros-Cid, E Martínez-Vila

  • 1Departamento de Neurología y Neurocirugía, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, España.

Revista De Neurologia
|November 12, 1998
PubMed
Summary
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Mitochondrial diseases like MELAS can cause cerebrovascular changes. This review covers clinical features, diagnostics, mechanisms, and treatments for these conditions.

Area of Science:

  • Neurology
  • Mitochondrial Biology
  • Vascular Medicine

Context:

  • Mitochondrial diseases are a group of inherited disorders affecting cellular energy production.
  • Cerebrovascular changes are increasingly recognized in certain mitochondrial disorders.
  • Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a prominent example.

Purpose:

  • To review mitochondrial diseases associated with cerebrovascular changes.
  • To focus on the clinical aspects, diagnostics, and pathophysiology of MELAS.
  • To discuss current and potential therapeutic strategies.

Summary:

  • This review examines mitochondrial disorders manifesting with cerebrovascular abnormalities, including MERRF and Kearns-Sayre syndrome.
  • Emphasis is placed on MELAS, detailing its clinical presentation, diagnostic approaches, and underlying pathophysiological mechanisms.

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  • Therapeutic interventions for cerebrovascular involvement in mitochondrial diseases are also considered.

    • Impact:

    • Provides a comprehensive overview of cerebrovascular manifestations in mitochondrial diseases.
    • Highlights the importance of recognizing and managing stroke-like episodes in MELAS.
    • Informs clinical practice and future research directions for these complex disorders.