[Mitochondrial diseases and stroke]
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Updated: Aug 3, 2026

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
Published on: June 23, 2023
P Irimia1, A Oliveros-Cid, E Martínez-Vila
1Departamento de Neurología y Neurocirugía, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, España.
Abstract:
We review the mitochondrial diseases in which cerebrovascular changes are seen, such as the MERRF syndrome (myoclonic epilepsy and ragged red fibers) or the Kearns-Sayre syndrome (progressive external ophthalmoplegia, retinitis pigmentaria, cerebellar disorders and disorders of cardiac conduction), focusing on the syndrome involving mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). We consider the different clinical aspects, diagnostic methods, pathophysiological mechanisms of the cerebrovascular involvement as well as therapeutic approaches.
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