[Mitochondrial changes in neurodegenerative diseases]
Related Experiment Video
Updated: Oct 27, 2026

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models
Published on: June 30, 2023
F J Jiménez-Jiménez1, M Ortí-Pareja, J A Molina-Arjona
1Sección de Neurología, Hospital Príncipe de Asturias, Universidad de Alcalá de Henares, España.
Abstract:
There are many data suggesting the possible role of oxidative reactions mediated by free radicals in neurodegenerative disease. Because the mitochondrial respiratory chain exerts a protective role against these reactions, its dysfunction could contribute to 'oxidative stress'. There have been described alterations of the mitochondrial respiratory chain and mitochondrial genome in several neurodegenerative diseases, such as in Parkinson's, Alzheimer's and Huntington's diseases. This article focuses on a review of the current knowledge regarding this issue.
Related Concept Videos
Alzheimer Disease ll: Pathophysiology
Mitochondria
Parkinson Disease ll: Pathophysiology
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Mitochondrial Membranes

